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Comparison of Zaditen-Intal and combined prophylaxis in asthmatic children
Insights
For severe childhood asthma, Zaditen and Intal equally reduced wheezing. Combination therapy proved most effective, with 50% of patients becoming symptom-free when using both Zaditen and Intal.
Area of Science:
- Pediatric Pulmonology
- Allergy and Immunology
Background:
- Asthma is a chronic respiratory condition affecting children worldwide.
- Prophylactic management is crucial for controlling severe asthma exacerbations.
- Identifying effective treatment regimens for pediatric asthma is an ongoing clinical challenge.
Purpose of the Study:
- To compare the efficacy of Zaditen and Intal as prophylactic treatments for severe childhood asthma.
- To evaluate the effectiveness of combination therapy for non-responsive asthma cases.
Main Methods:
- A randomized crossover study involving 28 children with severe asthma.
- Patients received Zaditen or Intal for 8 weeks, followed by a 2-week washout period.
- Non-responders were subsequently treated with a combination of Zaditen and Intal.
Main Results:
- Both Zaditen and Intal equally reduced the number and duration of wheezing episodes.
- 44% of patients showed a preference for Zaditen, while 32% preferred Intal.
- Combination therapy resulted in 50% of patients becoming symptom-free, indicating superior efficacy.
Conclusions:
- Zaditen and Intal demonstrate comparable efficacy in reducing asthma symptoms individually.
- Combination therapy offers a highly effective strategy for managing severe pediatric asthma, particularly in non-responsive cases.
Abstract:
The authors selected 28 severe asthmatic children in order to compare the effect of different prophylactic regimens. Patients experiencing at least one wheezing attack per week were included in the study. In a randomized manner, they were allocated Zaditen or Intal. After 8 weeks of active treatment and a 2 week wash-out period, the 2 groups switched over the drugs. Finally non-responders in both groups were placed on a combination of Zaditen and Intal. 44% of all patients preferred Zaditen, 32% Intal and 20% got better only if both drugs were given together. The number and duration of wheezing periods decreased with Intal and Zaditen therapy equally but 44% of patients responded only to one or the other of these drugs. The best results were achieved with combination therapy and 50% of the patients became symptom-free in this manner.