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Methadone dose and human sexual behavior.

T J Crowley, R Simpson

    The International Journal of the Addictions
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Higher doses of methadone may suppress sexual behavior in individuals undergoing treatment for addiction. This study found significant correlations between methadone dosage and sexual activity frequency in both males and females.

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    Area of Science:

    • Addiction Medicine
    • Pharmacology
    • Human Sexuality

    Background:

    • Methadone maintenance therapy is a common treatment for opioid addiction.
    • Potential side effects of methadone treatment, including impacts on sexual function, require further investigation.

    Purpose of the Study:

    • To investigate the relationship between methadone dosage and the frequency of sexual behaviors in former addicts.
    • To determine if methadone dose influences sexual activity in males and females undergoing addiction treatment.

    Main Methods:

    • A study involving 31 male and 17 female former addicts in methadone maintenance or drug-free treatment.
    • Sexual behaviors were assessed using questionnaires administered weekly over several weeks.
    • Data analysis focused on correlations between daily methadone dose (mg/kg) and sexual behavior frequency.

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    Main Results:

    • A significant negative correlation was observed between daily methadone dose and frequency of genital contacts (r = -.54) and organs (r = -.43) in females.
    • A significant negative correlation was found between daily methadone dose and frequency of ejaculation (r = -.31) in males.
    • The study, though open and nonblind, suggests a dose-dependent suppression of sexual behavior by methadone.

    Conclusions:

    • Higher doses of methadone may be associated with a reduction in sexual behavior frequency.
    • These findings highlight a potential impact of methadone pharmacotherapy on the sexual health of individuals in addiction treatment.
    • Further research with blinded protocols is warranted to confirm these observations.