Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complete heart block after sublingual nitroglycerin.

L Lancaster, P E Fenster

    Chest
    |July 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Severe chest pain led to a rare case of complete heart block and hypotension after sublingual nitroglycerin. This adverse reaction occurred during lidocaine infusion, not with either drug alone, in a patient without significant heart disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    On demand delivery and analysis of single molecules on a programmable nanopore-optofluidic device.

    Nature communications·2019
    Same author

    Structure of the ribosome at 5.5 A resolution and its interactions with functional ligands.

    Cold Spring Harbor symposia on quantitative biology·2003
    Same author

    The location of protein S8 and surrounding elements of 16S rRNA in the 70S ribosome from combined use of directed hydroxyl radical probing and X-ray crystallography.

    RNA (New York, N.Y.)·2000
    Same author

    Pathophysiologic correlates of thromboembolism in nonvalvular atrial fibrillation: II. Dense spontaneous echocardiographic contrast (The Stroke Prevention in Atrial Fibrillation [SPAF-III] study).

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·1999
    Same author

    Characterization of functionally active subribosomal particles from Thermus aquaticus.

    Proceedings of the National Academy of Sciences of the United States of America·1999
    Same author

    Additional antianginal and anti-ischemic efficacy of mibefradil in patients pretreated with a beta blocker for chronic stable angina pectoris.

    The American journal of cardiology·1997
    Same journal

    Wearable-derived activity and physiological changes following pleural intervention in malignant pleural effusion.

    Chest·2026
    Same journal

    The effect of a two-day stay at high altitude (2500 m) on right ventricular afterload and oxygen delivery in patients with pulmonary vascular disease A randomized controlled crossover trial.

    Chest·2026
    Same journal

    A Comparative Study of Radiation Exposure in Conventional and Robotic Bronchoscopy.

    Chest·2026
    Same journal

    Independent Prognostic Contributions of Anti-Ro52 and Anti-MDA5 in Autoimmune-Associated Interstitial Lung Disease.

    Chest·2026
    Same journal

    Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

    Chest·2026
    Same journal

    Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

    Chest·2026
    See all related articles

    Area of Science:

    • Cardiology
    • Clinical Pharmacology

    Background:

    • Severe chest pain necessitates careful patient monitoring.
    • Sublingual nitroglycerin is commonly used for chest pain management.
    • Lidocaine is an antiarrhythmic drug often used for cardiac conditions.

    Observation:

    • A 62-year-old man developed complete heart block and hypotension after sublingual nitroglycerin.
    • This adverse event occurred during a maintenance infusion of intravenous lidocaine.
    • Neither nitroglycerin nor lidocaine alone precipitated these cardiac complications.

    Findings:

    • The patient had no evidence of acute cardiac ischemia or significant underlying heart disease.
    • Complete heart block following sublingual nitroglycerin is an extremely rare phenomenon, especially without pre-existing cardiac pathology.

    Related Experiment Videos

  • The combination of sublingual nitroglycerin and intravenous lidocaine appeared to trigger this severe reaction.

    • Implications:

    • Clinicians should be aware of potential drug interactions between nitroglycerin and lidocaine.
    • This case highlights the importance of considering medication history in unexplained cardiac events.
    • Further investigation may be warranted to elucidate the specific mechanism of this rare drug interaction.