Related Experiment Videos
H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex
Immunogenetics
|January 1, 1983
Summary
This study details genes within the H-2 complex, defining it by class I and class II loci. It includes Qa and Tla loci as class I, presenting a genetic map based on molecular studies.
Area of Science:
- Immunogenetics
- Molecular Genetics
Background:
- The H-2 complex is a critical region of the mouse genome involved in immune responses.
- Previous listings have described associated complement and Neu-1 loci.
Purpose of the Study:
- To describe genes constituting the H-2 complex proper, including class I and class II loci.
- To present an updated genetic map of the H-2 complex based on molecular genetics.
- To review historically considered but uncertain loci associated with the H-2 complex.
Main Methods:
- Functional definition of the H-2 complex into class I and class II loci.
- Inclusion of Qa and Tla loci as class I loci.
- Compilation of genetic map data from molecular genetics studies.
Main Results:
- The H-2 complex is functionally defined by class I and class II loci.
- Qa and Tla loci are considered class I loci.
- An updated genetic map of established H-2 loci is presented, incorporating molecular genetics data.
Conclusions:
- The H-2 complex comprises class I and class II loci, with Qa and Tla included as class I.
- Molecular genetics studies have refined the understanding of the H-2 complex's genetic map.
- Historical and uncertain loci associated with H-2 are also discussed for completeness.