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Updated: Aug 9, 2026
10:19
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
An improved mechanical device for control of urinary incontinence
Investigative Urology
|March 1, 1978
Summary
Titanium alloy control units for artificial sphincters prevent failure caused by plastic deterioration. These new units showed no hampering of function due to tissue ingrowth or fibrosis in animal tests.
Area of Science:
- Biomedical Engineering
- Urology
- Materials Science
Background:
- Previous implantable artificial sphincter designs using plastic-encased control units failed due to material deterioration within 12-18 months.
- This plastic degradation led to instrument malfunction, limiting the long-term efficacy of the artificial urinary sphincter.
Purpose of the Study:
- To evaluate the functional performance and biocompatibility of novel titanium alloy control units for implantable artificial sphincters.
- To determine if fibrosis and tissue ingrowth impede the function of titanium alloy control levers in a subcutaneous environment.
Main Methods:
- Tested titanium alloy control units with protruding levers in 17 animals for up to 6 months.
- Implanted devices around the urethra distal to the bladder neck.
- Set devices to obstruct urethral pressures ranging from 40 to 80 cm of water.
Main Results:
- No urethral erosion was observed during the study period.
- The titanium alloy control levers were not hampered by tissue ingrowth or fibrosis.
- The subcutaneous placement of titanium alloy units proved to be a viable alternative to plastic casings.
Conclusions:
- Titanium alloy control units are a promising solution to overcome the failure modes associated with plastic components in artificial sphincters.
- The biocompatibility of titanium alloy ensures the long-term functionality of artificial urinary sphincter devices.
- Further research may focus on long-term implantation studies and human clinical trials.
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