Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma concentration of cutaneously applied trinitroglycerin.

D Magometschnigg, H Horwatitsch, M Pichler

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |April 1, 1983
    PubMed
    Summary

    Trinitroglycerin ointment absorption was studied over 12 hours in ten people. Absorption was detected within 10 minutes, peaking at 30 minutes, with effects like reduced blood pressure observed.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Rare soft tissue tumour of the skin of the chest].

    Der Radiologe·2021
    Same author

    Comparative analysis reveals within-population genome size variation in a rotifer is driven by large genomic elements with highly abundant satellite DNA repeat elements.

    BMC biology·2021
    Same author

    Cost-effectiveness analysis of the use of immunotherapy in metastatic solid tumours in Austria by applying the ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS) version 1.1.

    ESMO open·2021
    Same author

    Decrease in treatment intensity predicts worse outcome in patients with locally advanced head and neck squamous cell carcinoma undergoing radiochemotherapy.

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2020
    Same author

    Critical evaluation of platelet size as a prognostic biomarker in colorectal cancer across multiple treatment settings: a retrospective cohort study.

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2019
    Same author

    Long-term cardiovascular complications in stage I seminoma patients.

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2017

    Area of Science:

    • Pharmacology
    • Dermatology
    • Clinical Medicine

    Background:

    • Topical nitroglycerin is used for various conditions.
    • Understanding its absorption kinetics is crucial for effective dosing and managing side effects.

    Purpose of the Study:

    • To investigate the absorption profile of trinitroglycerin ointment.
    • To correlate absorption with observed physiological effects.

    Main Methods:

    • Ten healthy volunteers applied trinitroglycerin ointment.
    • Plasma concentrations were measured over a 12-hour period.
    • Physiological parameters (blood pressure, heart rate, headache) were monitored.

    Main Results:

    • Trinitroglycerin was detectable in plasma from 10 minutes post-application, with a peak at 30 minutes.
    • Absorption was sustained throughout the 12-hour study period.
    • Observed effects included decreased blood pressure, increased heart rate, and headaches.

    Conclusions:

    • Trinitroglycerin ointment demonstrates significant dermal absorption.
    • Variability in absorption and bioavailability influences individual responses.
    • The observed physiological effects are consistent with systemic absorption of trinitroglycerin.

    Related Experiment Videos