The major histocompatibility complex of the rat: a partial review

The major histocompatibility complex of the rat is now called RT1, and this name is becoming widely accepted. In the past five years many recombinants have been reported within RT1 that enable distinct functional regions to be identified and located relative to each other. RT1 does not at present look particularly like its closest known relative, H-2. No doubt the genetic relationship will become apparent at the DNA level. The spontaneous diabetes mellitus of the BB rat line is associated with RT1. The data so far suggest that RT1u supplies a dominant susceptibility that becomes apparent only if protection conferred by a dominant gene mapping outside the MHC is withdrawn. It seems likely that the BB rat carries a recessive mutation at this "protective" locus.