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Updated: Aug 10, 2026

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
Published on: March 16, 2015
[Studies on the genetics of otosclerosis (author's transl)]
Abstract:
101 families with confirmed otosclerosis were investigated, and after correction for age an incidence was found of otosclerosis of 29.5% amongst the parents, 17.9% amongst the siblings and 8.8% amongst offspring. The statistical data for otosclerosis published to date were treated similarly giving together with our own as large a collection as possible. From this the risk of repeat occurrence of otosclerosis could be calculated to 10% in the brothers and 20% in the sisters of otosclerotic patients. The risk rates of occurrence for their children are the same. These data are intended for use in the genetic counseling of this disorder.
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