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Embryotoxicity of phomopsin in rats
The Australian Journal of Experimental Biology and Medical Science
|February 1, 1983
Summary
Phomopsin, a mycotoxin causing lupinosis, led to significant embryonic mortality and growth retardation in pregnant rats. Toxicity was higher with repeated doses compared to single injections.
Area of Science:
- Toxicology
- Reproductive Biology
- Mycotoxicology
Background:
- Lupinosis is a disease caused by the mycotoxin phomopsin, produced by Phomopsis leptostromiformis.
- The teratogenic potential of phomopsin in mammals is not well-established.
Purpose of the Study:
- To investigate the effects of phomopsin on embryonic development in pregnant rats.
- To determine the dose-dependent toxicity and teratogenicity of phomopsin.
Main Methods:
- Pregnant rats were administered single or repeated doses of phomopsin at various stages of gestation.
- Embryonic development and fetal outcomes were assessed on day 20 of pregnancy.
Main Results:
- High doses of phomopsin (0.4 mg/kg single or 0.09 mg/kg repeated) caused significant embryonic mortality.
- Surviving fetuses exhibited severe growth retardation and irregular skeletal ossification.
- Repeated lower doses (0.03 mg/kg) over days 6-10 resulted in lower mortality.
- Maternal toxicity (lupinosis lesions) and embryonic toxicity were greater with prolonged exposure.
Conclusions:
- Phomopsin is a potent embryotoxin and fetotoxin in rats.
- The timing and duration of exposure influence phomopsin's toxicity.
- Further research is needed to fully elucidate the teratogenic profile of phomopsin.