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Successful rat pancreatic islet allotransplantation without recipient immunosuppression
Cellular Immunology
|July 15, 1983
Abstract:
Pancreatic islets from Wistar Furth (RT1u) rats are rejected by 5 days after transplantation into the liver of the diabetic Lewis (RT11) rat. Pretreatment of Wistar Furth islets by culture for 7-10 days in 95% O2 5% CO2 reduces immunogenicity permitting successful allotransplantation as defined by normal blood and 24-hr urinary glucose values.