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Related Experiment Videos

Immune function during ageing in man: relation between serological abnormalities and cellular immune status.

H M Lokhorst, J A van der Linden, H J Schuurman

    European Journal of Clinical Investigation
    |June 1, 1983
    PubMed
    Summary

    This study found that 38% of healthy older adults have cold lymphocytotoxic antibodies, but these serological abnormalities do not correlate with changes in immune cell function or composition in aging individuals.

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    Area of Science:

    • Immunology
    • Gerontology
    • Serology

    Background:

    • Ageing is associated with immune system changes, but specific serological abnormalities in healthy older adults require further investigation.
    • Previous studies show varying prevalences of monoclonal immunoglobulins and autoantibodies in elderly populations.

    Purpose of the Study:

    • To investigate the prevalence of serological abnormalities, specifically cold lymphocytotoxic antibodies, in healthy aged individuals.
    • To determine if these serological abnormalities correlate with immune cell composition and function in the elderly.

    Main Methods:

    • Studied 176 healthy individuals aged 62-86 years.
    • Assessed prevalence of monoclonal immunoglobulin, autoantibodies, and cold lymphocytotoxic antibodies.
    • Analyzed peripheral blood mononuclear cell composition (B and T lymphocyte subsets) and function (lymphocyte stimulation).

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  • Compared results with a control group of young blood donors.

    • Main Results:

    • 38% of healthy aged participants exhibited cold lymphocytotoxic antibodies.
    • No age dependency was observed for serological abnormalities.
    • No differences in B and T lymphocyte subsets or function were found between groups with and without serological abnormalities.
    • Lymphocyte stimulation responses were generally lower in older adults compared to young controls.

    Conclusions:

    • Humoral abnormalities in ageing, such as cold lymphocytotoxic antibodies, are not linked to alterations in B and T lymphocyte subsets or function.
    • While lymphocyte responses may decrease with age, specific serological findings in healthy elderly individuals do not appear to impact cellular immunity.