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[A hypothesis: multiple sclerosis a systemic disease].

E K Wong, H Ewomoto, R B Turner

    Journal Francais D'Ophtalmologie
    |January 1, 1983
    PubMed
    Summary
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    Multiple Sclerosis (MS) patients exhibit low plasma zinc levels and impaired erythrocyte membrane function, suggesting a potential systemic basis for the disease beyond the central nervous system.

    Area of Science:

    • Biochemistry
    • Ophthalmology
    • Metallochemistry

    Background:

    • Low plasma zinc levels are frequently observed in patients with Multiple Sclerosis (MS).
    • Previous studies have confirmed these low zinc levels globally.
    • Generalized malabsorption was ruled out in MS patients via fecal fat studies.

    Purpose of the Study:

    • To investigate the role of zinc metabolism and erythrocyte membrane function in Multiple Sclerosis.
    • To explore the potential of MS as a systemic disease based on metallochemical and biochemical findings.

    Main Methods:

    • A double-blind, randomized zinc tolerance test was conducted on MS patients and controls.
    • Fecal fat analysis was performed to assess for malabsorption.
    • Intracellular erythrocyte zinc concentration and membrane-bound CNP were measured.

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    Main Results:

    • MS patients showed low fasting plasma zinc levels, which normalized after oral zinc load.
    • Unlike controls, MS patients exhibited a significant increase in intracellular erythrocyte zinc over 7 hours post-load (P < 0.01).
    • Erythrocyte membranes in MS patients demonstrated an inability to maintain zinc gradients and had lower membrane-bound CNP.

    Conclusions:

    • MS patients have a functional abnormality in plasma membranes, affecting zinc transport.
    • The erythrocyte membrane's inability to regulate zinc gradients suggests a systemic issue in MS.
    • Findings support the consideration of Multiple Sclerosis as a systemic disease.