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Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes
12:50

Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes

Published on: August 9, 2011

Listeria monocytogenes in Northern Nigeria

G C Onyemelukwe, R V Lawande, L J Egler

    The Journal of Infection
    |March 1, 1983
    PubMed

    Insights

    Listeria monocytogenes infections, including meningitis and sepsis, affected diverse patients. Most strains were susceptible to common antibiotics, but a significant mortality rate was observed.

    Area of Science:

    • Clinical microbiology
    • Infectious diseases
    • Immunology

    Background:

    • Listeria monocytogenes is a significant human pathogen.
    • The bacterium can cause severe invasive infections.

    Purpose of the Study:

    • To describe the clinical spectrum of Listeria monocytogenes infections.
    • To characterize the isolates and their antibiotic susceptibility.
    • To report patient outcomes.

    Main Methods:

    • Prospective study over one year.
    • Isolation and serotyping of Listeria monocytogenes.
    • Clinical data collection.
    • Antibiotic susceptibility testing.

    Main Results:

    • Nineteen patients presented with various infections including meningitis, septicaemia, and peritonitis.
    • All isolates were serotype 4.
    • Patients with compromised immune systems and healthy individuals were affected.
    • Lymphocyte subtyping revealed T cells in one peritonitis case.
    • Most isolates were sensitive to ampicillin, penicillin, and erythromycin.
    • A 27% mortality rate was recorded.

    Conclusions:

    • Listeria monocytogenes infections present with a broad range of clinical manifestations.
    • Serotype 4 is a common cause of invasive listeriosis.
    • Prompt antibiotic treatment is crucial, but mortality remains a concern.

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