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Pancreatitis and intravenous fat: an association in patients with inflammatory bowel disease
Insights
Adding Intralipid to total parenteral nutrition (TPN) for pediatric inflammatory bowel disease (IBD) patients undergoing surgery was linked to acute pancreatitis. This highlights potential risks of fat emulsions in TPN for IBD patients post-resection.
Area of Science:
- Gastroenterology and Hepatology
- Pediatric Surgery
- Nutritional Support
Background:
- Inflammatory bowel disease (IBD) management often requires nutritional support.
- Total parenteral nutrition (TPN) is used when enteral feeding is not feasible.
- Intralipid (IL), an emulsified fat solution, is a component of TPN.
Purpose of the Study:
- To report two cases of acute pancreatitis in pediatric IBD patients post-major intestinal resection.
- To discuss the potential multifactorial etiologies of acute pancreatitis in this context.
- To review the role and risks of emulsified fat solutions in TPN for pediatric IBD patients.
Main Methods:
- Case report presentation of two pediatric patients with IBD.
- Review of clinical data and outcomes.
- Literature review on acute pancreatitis and TPN in IBD.
Main Results:
- Two children with IBD developed acute pancreatitis early postoperatively after receiving TPN with Intralipid.
- The pancreatitis occurred following major intestinal resections.
Conclusions:
- The addition of Intralipid to TPN regimens may be associated with an increased risk of acute pancreatitis in pediatric IBD patients after major intestinal resection.
- Further investigation into the role of emulsified fat solutions in TPN for this vulnerable population is warranted.
Abstract:
Since recently adding Intralipid (IL) to our standard total parenteral nutrition (TPN) regimen for children with inflammatory bowel (IBD) disease, two children undergoing major intestinal resections have developed acute pancreatitis in the early postoperative period. Herein, we present the clinical summaries of these two patients, discuss the multifactoral etiologies of acute pancreatitis, and review the role of emulsified fat solutions in TPN in children with IBD.