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Updated: Aug 18, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
The possible role of tyrosinase in malignant growth
Abstract:
The sera of patients who suffer from melanoma and mammary carcinoma show higher tyrosinase activity than normal sera. The enzyme tyrosinase oxidizes tyrosine to DOPA and also catalizes the oxidation of DOPA to Melanin. The catalytic oxidation might also occur in tyrosine while it is conjugated to other amino acids in a polypeptide or a protein molecule. It is theorized here that gamma globulins and interferons are vulnerable to this catalytic oxidation which eventually denaturates them and diminishes their immunological properties.
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