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Epidemiological studies of Pseudomonas aeruginosa infections in leg ulcers
Abstract:
A 6-month prospective study was carried out in an angiology ward on patients with leg ulcers. Pseudomonas aeruginosa was isolated from about half of the samples from the patients. Of the isolates, 85 were serotyped, fingerprinted as to passive pyocin sensitivity and characterized for antibiotic susceptibility pattern. According to all criteria, the isolates belonged to six strains, two of which were clearly epidemic: one infected 11 patients yielding 52 identical isolates, the other infected 4 patients (19 isolates).
Insights
Pseudomonas aeruginosa is a common cause of leg ulcers. This study identified six strains, with two epidemic strains causing most infections in patients with leg ulcers.
Area of Science:
- Medical Microbiology
- Clinical Angiology
Background:
- Leg ulcers are a significant clinical challenge, often complicated by bacterial infections.
- Pseudomonas aeruginosa is a frequent pathogen in chronic wounds, necessitating strain characterization.
Purpose of the Study:
- To investigate the prevalence and characteristics of Pseudomonas aeruginosa strains in patients with leg ulcers.
- To identify epidemic strains and their antibiotic susceptibility patterns.
Main Methods:
- Prospective study of patients with leg ulcers over 6 months.
- Isolation and characterization of Pseudomonas aeruginosa, including serotyping, pyocin typing, and antibiotic susceptibility testing.
- Analysis of 85 Pseudomonas aeruginosa isolates.
Main Results:
- Pseudomonas aeruginosa was isolated from approximately 50% of leg ulcer samples.
- Six distinct strains of Pseudomonas aeruginosa were identified among the isolates.
- Two epidemic strains were identified, one infecting 11 patients (52 isolates) and another infecting 4 patients (19 isolates).
Conclusions:
- Pseudomonas aeruginosa is a prevalent pathogen in leg ulcers, with specific strains dominating.
- The identification of epidemic strains is crucial for infection control in clinical settings.
- Understanding strain characteristics aids in managing Pseudomonas aeruginosa leg ulcer infections.