[Effect of the A-factor on the adenylate level in Streptomyces griseus]

The adenylate content of various strains of Streptomyces griseus was measured. With respect to the ATP and ADP content the strains capable of spore formation, streptomycin synthesis and A-factor (2-isocapryloyl-3-hydroxymethyl-4-hydroxybutyrolactone) synthesis differed from the A-factor deficient mutants. The addition of the A-factor to the recipient strains decreased the intracellular content of ATP and the ATP/ADP ratio. The strain which is not an A-factor recipient did not modify the ATP content when the A-factor was added to the medium.