Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transpleural CO2 diffusion in excised dog lungs.

J W Shepard, G F Dolan

    Respiration Physiology
    |May 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals that end-tidal CO2 measurements overestimate the transpleural gradient, leading to inaccurate calculations of pleural diffusing capacity. Convective mixing plays a key role in gas diffusion across the pleura.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists.

    Neurology·2007
    Same author

    Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease.

    Sleep medicine·2006
    Same author

    Cardiac arrhythmias during normal sleep and in obstructive sleep apnea syndrome.

    Sleep medicine reviews·2004
    Same author

    Pseudocataplexy.

    Psychosomatics·2001
    Same author

    The effect of snoring and obstructive sleep apnea on the sleep quality of bed partners.

    Mayo Clinic proceedings·2000
    Same author

    Recommendations for research into measurement and classification of sleep disordered breathing: gazing into the crystal ball.

    Sleep·1999

    Area of Science:

    • Pulmonary Physiology
    • Respiratory Mechanics
    • Gas Exchange

    Background:

    • Conflicting reports exist on transpleural gas diffusion relationships.
    • The role of convective mixing and end-tidal gas measurements in estimating pleural gradients needs clarification.

    Purpose of the Study:

    • To investigate the relationship between CO2 elimination and the transpleural CO2 gradient.
    • To assess the accuracy of end-tidal gas measurements in estimating subpleural gas tensions.
    • To explain discrepancies in previous transpleural gas diffusion studies.

    Main Methods:

    • Excised nonperfused dog lungs were ventilated with varying frequency, tidal volume, and pleural CO2.
    • CO2 elimination (VCO2) and transpleural CO2 gradient (FplCO2-FETCO2) were measured.

    Related Experiment Videos

  • Ultrastructural analysis examined type II pneumocyte lamellar body volume density.

    • Main Results:

    • A linear relationship was observed between VCO2 and the estimated transpleural CO2 gradient under constant ventilation.
    • Pleural CO2 diffusing capacity (DplCO2) decreased with reduced ventilation (frequency or tidal volume).
    • Alveolar CO2 near the pleural surface was higher than estimated by FETCO2, indicating overestimation of the gradient.

    Conclusions:

    • End-tidal CO2 measurements overestimate the transpleural CO2 gradient.
    • This overestimation leads to erroneously low estimates of pleural diffusing capacity.
    • Convective mixing and accurate pleural gradient estimation are crucial for understanding gas diffusion.