[Serologic determination of non-A, non-B hepatitis]

As to the antigens of hepatitis non-A non-B there are controversial opinions concerning existence and demonstrability. Up to now they were not successful neither in standardizing nor in unifying their test systems. On the basis of own investigations of 1,600 sera of patients with hepatitis non-A non-B and of several control groups, no doubt, a high incidence of precipitations among the sera of hepatitis non-A non-B could be established, but we did not succeed in standardizing the material which was uniform also with regard to the causing virus. Since real antigen-antibody reactions are causative for the heterogeneous phenomena, there nature is to establish by means of suitable methods (methods of the 3rd generation, monoclonal antibodies).