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Flow in experimental berry aneurysms: method and model.

C W Kerber, C B Heilman

    AJNR. American Journal of Neuroradiology
    |May 1, 1983
    PubMed
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    Fluid flow dynamics in aneurysms are influenced by bifurcation geometry. Lip asymmetry and rapid flow promote turbulent flow within aneurysms, potentially affecting adhesive retention.

    Area of Science:

    • Biomedical Engineering
    • Fluid Dynamics
    • Medical Device Design

    Background:

    • Aneurysms pose significant clinical challenges, and understanding their hemodynamics is crucial for developing effective treatments.
    • Current knowledge on how fluid flow dynamics within aneurysms influence their formation and progression remains incomplete.
    • Modifying intra-aneurysmal flow could enhance the retention of therapeutic agents, such as adhesives.

    Purpose of the Study:

    • To investigate the fluid flow dynamics within various aneurysm models.
    • To explore how aneurysm position and neck characteristics affect flow patterns.
    • To determine if flow modification can enhance the retention of adhesives within aneurysms.

    Main Methods:

    • Utilized Pyrex glass bifurcation models with varying aneurysm placements and neck configurations.

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  • Employed high-speed cinematography and 35 mm slide analysis to visualize fluid flow.
  • Introduced indicators into fluid streams to track flow patterns and turbulence.

    • Main Results:

    • A central slipstream impacting the bifurcation apex was observed even at low flow rates, potentially contributing to berry aneurysm formation.
    • A low-pressure zone at the lateral angle of bifurcations may explain endovascular cushion development.
    • Flow into symmetrically placed, narrow-neck aneurysms was negligible.
    • Turbulent flow within aneurysms occurred primarily with orifice (lip) asymmetry and rapid flow conditions.

    Conclusions:

    • Bifurcation geometry significantly dictates intra-aneurysmal flow dynamics.
    • Lip asymmetry and high flow rates are key factors promoting turbulent flow within aneurysms.
    • Understanding these flow characteristics is essential for designing strategies to improve adhesive retention in aneurysm treatment.