Computer analysis of orbital fat and muscle volumes in Graves ophthalmopathy

A technique using special computer programs and data from high-resolution computed tomographic scans has been developed that provides accurate and reproducible volume measurements for muscle and fat in the orbit. Normal values for retrobulbar fat and muscle were established in 19 adults. Nineteen patients with Graves exophthalmopathy were then studied, and a spectrum of change was found that included varying degrees of increased muscle volume or increased volume of both muscle and fat. Further categorization of these changes related to clinical characteristics should lead to a better understanding of the mechanism for ophthalmopathy in Graves disease.