Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective IgA deficiency in blood donors.

J A Clark, P A Callicoat, N A Brenner

    American Journal of Clinical Pathology
    |August 1, 1983
    PubMed
    Summary

    Selective Immunoglobulin A (IgA) deficiency was found in 0.30% of healthy blood donors, the highest reported prevalence. This study also identified a high prevalence of anti-IgA antibodies in affected individuals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    What are the 100 most cited fungal genera?

    Studies in mycology·2024
    Same author

    Efficacy of Fungicides on Sclerotinia sclerotiorum and Their Potential for Control of Sclerotinia Stem Rot on Soybean.

    Plant disease·2019
    Same author

    First Report of Phomopsis longicolla from Velvetleaf Causing Stem Lesions on Inoculated Soybean and Velvetleaf Plants.

    Plant disease·2019
    Same author

    Response of Ancestral Soybean Lines and Commercial Cultivars to Rhizoctonia Root and Hypocotyl Rot.

    Plant disease·2019
    Same author

    Quality of Harvested Seed Associated with Soybean Cultivars and Herbicides Under Weed-Free Conditions.

    Plant disease·2019
    Same author

    First Report of White Leaf Spot of Dry Bean Caused by Pseudocercosporella albida in North America.

    Plant disease·2019

    Area of Science:

    • Immunology
    • Hematology

    Background:

    • Selective Immunoglobulin A (IgA) deficiency is a primary immunodeficiency.
    • Understanding its prevalence in healthy populations is crucial for transfusion medicine and diagnostics.

    Purpose of the Study:

    • To determine the prevalence of selective IgA deficiency in a large, healthy blood donor population.
    • To assess the co-occurrence of anti-IgA antibodies in individuals with selective IgA deficiency.

    Main Methods:

    • Screening of 6,240 healthy blood donors for IgA deficiency using double-diffusion analysis.
    • Confirmation of IgA deficiency (serum level < 50 mg/L) via passive hemagglutination inhibition assay.
    • Detection of anti-IgA antibodies in donor sera.

    Main Results:

    • A prevalence of 0.30% (1 in 328) for selective IgA deficiency was observed, representing the highest reported in a healthy population.
    • Anti-IgA antibodies were detected in 36.8% of donors with selective IgA deficiency, also a record high.
    • Literature review on IgA deficiency and treatment considerations for blood product recipients.

    Conclusions:

    • The study reveals a significantly high prevalence of selective IgA deficiency and anti-IgA antibodies in healthy blood donors.
    • Findings have implications for blood product safety and management of IgA-deficient patients.
    • Further research into the clinical significance and management of this condition is warranted.

    Related Experiment Videos