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Related Experiment Videos

Coccidioidal spondylitis.

W G Winter, R K Larson, J P Zettas

    The Journal of Bone and Joint Surgery. American Volume
    |March 1, 1978
    PubMed
    Summary

    Disseminated coccidioidomycosis can cause spinal infections. Most patients treated with amphotericin B and surgery recovered well, though some experienced long-term neurological issues or died from complications.

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    Reviews of infectious diseases·1990

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Neurosurgery

    Background:

    • Disseminated coccidioidomycosis is a serious fungal infection.
    • Spinal involvement presents unique challenges in diagnosis and treatment.

    Purpose of the Study:

    • To review outcomes of spinal infections caused by disseminated coccidioidomycosis.
    • To evaluate the long-term prognosis and complications in affected patients.

    Main Methods:

    • Retrospective review of twelve cases with disseminated coccidioidomycosis and spinal infection.
    • Analysis of treatment modalities including amphotericin B, surgery, and spine fusion.
    • Assessment of patient outcomes, including survival, recurrence, and neurological sequelae.

    Main Results:

    • Eight of twelve patients achieved long-term remission (average 11 years post-onset).
    • Complications included neurological impairment (3 patients), paraplegia, and coccidioidal meningitis.
    • Intravenous amphotericin B was used in all cases; surgical intervention was common.

    Conclusions:

    • Disseminated coccidioidomycosis with spinal involvement can have a favorable long-term outcome with appropriate treatment.
    • Prompt surgical intervention and antifungal therapy are crucial for managing spinal coccidioidomycosis.
    • Neurological complications and meningitis remain significant risks, necessitating vigilant monitoring.

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