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Updated: Aug 9, 2026

The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma
Published on: October 9, 2015
Endothelial cell origin of thorium oxide-induced angiosarcoma of liver
Abstract:
A 72-year-old woman was found at autopsy to have hepatic angiosarcoma approximately 30 years after systemic thorium oxide (Thorotrast) injection. Intracytoplasmic localization of factor VIII-related antigen was demonstrated by an immunoperoxidase method, confirming the endothelial cell origin of the tumor.
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