A benzodiazepine antagonist is an anticonvulsant in an animal model for limbic epilepsy

A benzodiazepine antagonist, Ro 15-1788, completely abolishes the sedative/ataxic effects of diazepam but, at the same dose (10 mg/kg, i.p.), it, like diazepam, slows the development of kindled seizures. This suggests that the anticonvulsant and sedative effects of benzodiazepines are mediated via different receptors and that Ro 15-1788 or similar compounds may be useful anticonvulsants.