[Normalization of VEP in multiple sclerosis? Course observation in 50 of 500 MS patients]

Serial recordings of pattern-reversal VEPs have been performed in 50 of 500 MS patients in 4 or more occasions within the last 5 years. 49/96 eyes initially displayed a normal and 47/96 a prolonged P2 latency. A further delay was observed in 9 eyes, while in another 9 eyes the latency improved entering the normal range but in 4 eyes. In two eyes, only, shape and peak configuration normalized too. These results demonstrate the rarity of true normalisation of the contrast VEP after optical neuritis in MS.