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D-amphetamine in obsessive-compulsive disorder.

T R Insel, J A Hamilton, L B Guttmacher

    Psychopharmacology
    |January 1, 1983
    PubMed
    Summary
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    Single doses of d-amphetamine significantly improved obsessive-compulsive disorder (OCD) symptoms and attention in patients. This improvement correlated with self-rated activation and altered reality, but not with subsequent clomipramine treatment response.

    Area of Science:

    • Psychiatry
    • Neuroscience
    • Pharmacology

    Background:

    • Obsessive-compulsive disorder (OCD) is a severe chronic mental health condition.
    • Current treatments for OCD have limitations, necessitating exploration of novel therapeutic avenues.

    Purpose of the Study:

    • To investigate the acute effects of d-amphetamine on severe chronic obsessive-compulsive disorder (OCD) symptoms.
    • To explore the relationship between d-amphetamine response and cognitive function, specifically attention.

    Main Methods:

    • A double-blind, crossover study design was employed.
    • Twelve patients with severe chronic OCD received single doses of d-amphetamine and placebo.
    • Clinical ratings, attention task performance, and self-rated measures of activation and altered reality were assessed.

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    Main Results:

    • Significant improvement in obsessive-compulsive symptoms was observed with d-amphetamine compared to placebo.
    • Symptom improvement correlated with enhanced performance on an attention task.
    • Self-rated measures of activation and altered reality also showed significant changes.

    Conclusions:

    • Acute administration of d-amphetamine demonstrates potential in alleviating obsessive-compulsive symptoms and improving attentional performance in severe chronic OCD.
    • The behavioral response to d-amphetamine was not predictive of response to clomipramine in this cohort.
    • Further research is warranted to explore the therapeutic potential of amphetamines in OCD management.