Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Is valproic acid teratogenic?].

E Robert, J M Robert, C Lapras

    Revue Neurologique
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Valproic acid, an anti-epileptic drug, is linked to a higher incidence of spina bifida aperta in infants born to epileptic mothers. This study explores the connection and suggests preventive measures.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Efficacy of immune checkpoint inhibitors in patients with xeroderma pigmentosum and advanced cutaneous squamous-cell carcinoma and literature review.

    Annales de dermatologie et de venereologie·2026
    Same author

    [Epidemiology of burns in mayotte in 2022: an exhaustive study on a particular health area].

    Annals of burns and fire disasters·2025
    Same author

    Demonstration for cold atmospheric pressure plasma jet operation and antibacterial action in microgravity.

    NPJ microgravity·2024
    Same author

    Symptoms and management of cow's milk allergy: perception and evidence.

    Frontiers in allergy·2024
    Same author

    Sustained xanthophyll pigments-related photoprotective NPQ is involved in photoinhibition in the haptophyte Tisochrysis lutea.

    Scientific reports·2023
    Same author

    [Shape and aesthetic outcome evaluation of transposed umbilicus according to four surgical procedures].

    Annales de chirurgie plastique et esthetique·2020
    Same journal

    Geographic disparities in MRI features of ischemic stroke and small vessel disease: A comparative study between French Guiana and mainland France. Findings from the BECATOUR multicenter registry.

    Revue neurologique·2026
    Same journal

    Continuous subcutaneous perfusion of apomorphine in Parkinson's disease: Towards monotherapy?

    Revue neurologique·2026
    Same journal

    Neuro-Whipple presenting as autoimmune encephalitis.

    Revue neurologique·2026
    Same journal

    Multimodal assessment of minimally conscious state and cognitive motor dissociation in neurocritical care: A critical review.

    Revue neurologique·2026
    Same journal

    Development of a new episodic memory assessment tool (NEM): Preliminary data and clinical perspectives.

    Revue neurologique·2026
    Same journal

    Novel variants and rare clinical presentations in MFN2-related Charcot-Marie-Tooth disease: Insights from 10 families.

    Revue neurologique·2026
    See all related articles

    Area of Science:

    • Neurology
    • Teratology
    • Public Health

    Context:

    • Neonatal malformations registry data up to 1982.
    • Analysis of 7,000+ cases.
    • Focus on infants born to epileptic mothers.

    Purpose:

    • Investigate the association between maternal epilepsy treatment and specific birth defects.
    • Examine the risk of spina bifida aperta.
    • Propose a pathogenic hypothesis and preventive strategies.

    Summary:

    • A significantly increased rate of spina bifida aperta was observed in infants whose mothers used valproic acid.
    • This finding emerged from a regional computer register of over 7,000 neonatal malformations.
    • The study links valproic acid exposure during pregnancy to this specific neural tube defect.

    Related Experiment Videos

    Impact:

    • Highlights potential teratogenic effects of valproic acid.
    • Informs clinical practice regarding anti-epileptic drug use in pregnancy.
    • Suggests the need for enhanced prenatal screening and preventive interventions for neural tube defects.