Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amiodarone and thyroid function: clinical implications during antiarrhythmic therapy.

B N Singh, K Nademanee

    American Heart Journal
    |October 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mechanistic and recent updates in nano-bioremediation for developing green technology to alleviate agricultural contaminants.

    International journal of environmental science and technology : IJEST·2022
    Same author

    A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys.

    Computers in biology and medicine·2022
    Same author

    How is Biodegradable Scaffold Effective in Gap Non-union? Insights from an Experiment.

    Indian journal of orthopaedics·2021
    Same author

    Computational exploration and anti-mycobacterial activity of potential inhibitors of <i>Mycobacterium tuberculosis</i> acetyl coenzyme A carboxylase as anti-tubercular agents.

    SAR and QSAR in environmental research·2021
    Same author

    Fabrication and evaluation of non-mulberry silk fibroin fiber reinforced chitosan based porous composite scaffold for cartilage tissue engineering.

    Tissue & cell·2018
    Same author

    Studies on effect of CuO addition on mechanical properties and in vitro cytocompatibility in 1393 bioactive glass scaffold.

    Materials science & engineering. C, Materials for biological applications·2018

    Amiodarone therapy affects thyroid hormones, increasing thyroxine (T4) and reverse T3 (rT3). Monitoring serum rT3 levels can predict amiodarone

    Area of Science:

    • Cardiology
    • Endocrinology
    • Pharmacology

    Background:

    • Amiodarone, a benzofuran derivative, exhibits electrophysiologic effects similar to hypothyroidism.
    • Its therapeutic action may involve inhibiting triiodothyronine (T3) in the myocardium.

    Observation:

    • Amiodarone alters thyroid hormone levels, notably increasing thyroxine (T4) and reverse T3 (rT3), while slightly decreasing T3.
    • Thyroid-stimulating hormone shows minor, transient increases, and thyroid-binding globulin remains unaffected.
    • Iodine content in amiodarone can rarely induce hypothyroidism or hyperthyroidism, independent of its direct pharmacologic effects.

    Findings:

    • Serum rT3 levels correlate with amiodarone dose and therapy duration, reflecting in vivo drug accumulation.
    • Therapeutic efficacy is linked to achieving specific serum rT3 ranges.

    Related Experiment Videos

  • Serious adverse effects are associated with marked rT3 elevations and resolve upon reduction or discontinuation of amiodarone.

    • Implications:

    • Serum rT3 monitoring offers a reliable method to assess amiodarone's antiarrhythmic efficacy and toxicity.
    • This monitoring can guide the development of safer, optimized therapeutic regimens for refractory tachyarrhythmias.
    • Clinical utility is enhanced by using rT3 levels, accounting for assay variations and patient conditions.