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Related Experiment Videos

Abnormal liver-spleen scan associated with hyperviscosity syndrome.

T H Guthrie, W C Fortson, D R Spearman

    Archives of Internal Medicine
    |September 1, 1983
    PubMed
    Summary

    Hyperviscosity syndrome can cause abnormal liver scans. Plasmapheresis confirmed these liver scan defects were not cancerous, suggesting a new diagnostic consideration.

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    Area of Science:

    • Hepatology
    • Nuclear Medicine
    • Hematology

    Background:

    • Hyperviscosity syndrome presents with diverse clinical manifestations.
    • Liver radionuclide scans are used to assess hepatic function and morphology.
    • Liver biopsies carry risks, especially in patients with bleeding diatheses.

    Observation:

    • A patient with hyperviscosity syndrome exhibited abnormal patchy labeling on a liver radionuclide scan.
    • Ultrasound examination provided complementary anatomical data.
    • The liver scan abnormalities resolved following plasmapheresis.

    Findings:

    • The patchy labeling defects on the liver scan were confirmed to be non-neoplastic.
    • This case identifies hyperviscosity syndrome as a novel cause of liver scan abnormalities.
    • Resolution post-plasmapheresis supports the link between viscosity and scintigraphic findings.

    Implications:

    • This finding offers a non-invasive method to evaluate liver abnormalities in hyperviscosity syndrome.
    • It highlights the importance of considering systemic conditions when interpreting liver imaging.
    • Understanding these scintigraphic patterns can aid in avoiding hazardous liver biopsies.

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