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[Changes in passive left ventricular pressure-volume relations in acute volume expansion]
Archives Des Maladies Du Coeur Et Des Vaisseaux
|July 1, 1983
Summary
Acute volumic expansion shifts the passive left ventricular pressure-volume relationship upwards and leftward. This change is primarily due to increased intrapericardial pressure, not altered left ventricular distensibility.
Area of Science:
- Cardiology
- Physiology
- Biomedical Engineering
Context:
- The passive left ventricular pressure-volume relationship assesses cardiac distensibility.
- Acute interventions can alter this relationship, challenging standard interpretations.
- Assessing left ventricular function assumes a stable pressure-volume relationship during volume expansion.
Purpose:
- To investigate the impact of acute volumetric expansion on the passive left ventricular pressure-volume relationship.
- To determine if left ventricular distensibility changes during rapid volume loading.
- To evaluate the validity of left ventricular function curves under acute volume expansion.
Summary:
- Twelve patients without heart disease underwent rapid volumetric expansion.
- Measurements included cardiac output, ventricular pressures, and volumes/diameters.
- The passive pressure-volume and pressure-diameter relationships shifted upwards and leftward, primarily due to increased intrapericardial pressure.
Impact:
- Acute volumetric expansion significantly alters the passive left ventricular pressure-volume relationship.
- Increased intrapericardial pressure is a key factor in this shift.
- Standard left ventricular function curves are unreliable for assessing systolic function during acute volume expansion; end-diastolic pressure does not reflect end-diastolic volume.