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Updated: Jul 27, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

Experimental models of atherosclerosis regression.

Atherosclerosis

|August 1, 1983

Summary

Atherosclerosis regression is observed in many animal models and can be induced by dietary changes or specific compounds. Further research is needed to confirm if animal atherosclerosis regression mirrors human responses.

Area of Science:

Cardiovascular Science
Animal Models
Medical Research

Background:

Atherosclerosis regression, the reversal of plaque buildup, has been observed in various animal species.
Dietary cholesterol withdrawal and interventions like cholestyramine or alfalfa saponins have induced regression in animal models.

Purpose of the Study:

To review the evidence for atherosclerosis regression in animal models.
To highlight the need for establishing the correspondence between animal and human atherosclerosis regression.

Main Methods:

Review of existing studies demonstrating atherosclerosis regression in animals.
Identification of interventions associated with regression in animal models.
Comparison with documented human atherosclerosis regression.

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Quantification of Atherosclerosis in Mice

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Last Updated: Jul 27, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 8, 2013

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

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Published on: February 20, 2019

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Main Results:

Atherosclerosis regression is a documented phenomenon across multiple animal species (rabbits, chickens, rats, dogs, pigeons, pigs, nonhuman primates).
Regression in animals is linked to cholesterol withdrawal or specific dietary components (cholestyramine, alfalfa meal, alfalfa saponins).

Conclusions:

Atherosclerosis regression is achievable in diverse animal models.
Establishing the direct correlation between animal and human atherosclerosis regression is crucial for translational research.