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Related Experiment Videos

Plasma amine and hormone changes in 'post-partum blues'.

V Kuevi, R Causon, A F Dixson

    Clinical Endocrinology
    |July 1, 1983
    PubMed
    Summary

    Postpartum blues in mothers are linked to lower levels of catecholamines, specifically noradrenaline and adrenaline. Hormone levels like FSH and prolactin showed no significant correlation with these mood disturbances.

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    Area of Science:

    • Neuroendocrinology
    • Reproductive Psychiatry

    Background:

    • Postpartum blues affect a significant percentage of mothers.
    • The interplay between hormones, neurotransmitters, and mood in the postpartum period requires further elucidation.

    Purpose of the Study:

    • To investigate the relationship between hormone levels, plasma catecholamines, and mood disturbances in the early postpartum period.
    • To identify potential biomarkers for postpartum emotional lability.

    Main Methods:

    • Plasma levels of hormones (FSH, prolactin, oestrone, oestradiol, cortisol, progesterone) and catecholamines (noradrenaline, adrenaline) were measured.
    • Mood disturbances were assessed in 44 mothers during days 2-5 postpartum.

    Main Results:

    • No significant correlation was found between hormone levels and postpartum blues.

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  • A significant reduction in circulating catecholamines correlated with mood disturbances.
  • Mothers experiencing postpartum blues had lower levels of noradrenaline and adrenaline on affected days.

    • Conclusions:

    • Catecholamine levels, not reproductive hormones, appear to be associated with early postpartum mood disturbances.
    • Reduced noradrenaline and adrenaline may contribute to the emotional lability observed in postpartum blues.