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Morphological and somatic clonal analyses of pattern triplications.

J R Girton

    Developmental Biology
    |September 1, 1983
    PubMed
    Summary

    Pattern triplications in fruit fly larvae reveal distinct growth patterns. Some arise from original cells, while others involve new, regulative growth, supporting the polar coordinate model.

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    Developmental biology·1982

    Area of Science:

    • Developmental biology
    • Genetics
    • Cell biology

    Background:

    • Pattern triplications can arise in fruit fly larvae under specific temperature treatments.
    • Understanding the cellular origins of these triplications is key to developmental mechanisms.

    Purpose of the Study:

    • To differentiate between structures formed by original imaginal disc cells and those resulting from new, regulative growth in pattern triplications.
    • To investigate the contribution of original versus newly grown cells in different types of pattern triplications.

    Main Methods:

    • Induction of pattern triplications using a temperature-sensitive (ts) cell-lethal mutation in fruit fly larvae.
    • Morphological analyses of triplication patterns.
    • Somatic clonal analysis to trace cell lineage and growth.

    Main Results:

    • In 'divergent' triplications, the original leg pattern contributes to the paradrome, while the antidrome and orthodrome result from extra growth.
    • In 'convergent' triplications, the orthodrome originates from the original pattern, with the antidrome and paradrome arising from extra growth.
    • Findings align with predictions from the polar coordinate model of positional information.

    Conclusions:

    • The study elucidates the cellular basis of pattern triplication formation in fruit flies.
    • Results support the polar coordinate model's explanation of pattern formation and regeneration.
    • Distinguishing between original and regulative growth provides insights into developmental plasticity.

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