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Morphological and somatic clonal analyses of pattern triplications.

J R Girton

    Developmental Biology
    |September 1, 1983
    PubMed
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    Pattern triplications in fruit fly larvae reveal distinct growth patterns. Some arise from original cells, while others involve new, regulative growth, supporting the polar coordinate model.

    Area of Science:

    • Developmental biology
    • Genetics
    • Cell biology

    Background:

    • Pattern triplications can arise in fruit fly larvae under specific temperature treatments.
    • Understanding the cellular origins of these triplications is key to developmental mechanisms.

    Purpose of the Study:

    • To differentiate between structures formed by original imaginal disc cells and those resulting from new, regulative growth in pattern triplications.
    • To investigate the contribution of original versus newly grown cells in different types of pattern triplications.

    Main Methods:

    • Induction of pattern triplications using a temperature-sensitive (ts) cell-lethal mutation in fruit fly larvae.
    • Morphological analyses of triplication patterns.
    • Somatic clonal analysis to trace cell lineage and growth.

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    Main Results:

    • In 'divergent' triplications, the original leg pattern contributes to the paradrome, while the antidrome and orthodrome result from extra growth.
    • In 'convergent' triplications, the orthodrome originates from the original pattern, with the antidrome and paradrome arising from extra growth.
    • Findings align with predictions from the polar coordinate model of positional information.

    Conclusions:

    • The study elucidates the cellular basis of pattern triplication formation in fruit flies.
    • Results support the polar coordinate model's explanation of pattern formation and regeneration.
    • Distinguishing between original and regulative growth provides insights into developmental plasticity.