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Gadolinium as a contrast agent for NMR.
AJNR. American Journal of Neuroradiology
|September 1, 1983
Summary
Gadolinium chloride (GdCl3) shows promise as a nuclear magnetic resonance contrast agent, significantly decreasing T1 relaxation times in mouse plasma, kidney, and liver tissues. Further research is warranted to explore its full potential and safety profile.
Area of Science:
- Medical Imaging
- Biophysics
- Toxicology
Background:
- Gadolinium chloride (GdCl3) is a rare-earth element with significant paramagnetic properties.
- Nuclear Magnetic Resonance (NMR) imaging relies on contrast agents to enhance signal detection.
- The paramagnetic moment of GdCl3 is 10.8 Bohr magnetons, indicating strong magnetic influence.
Purpose of the Study:
- To evaluate Gadolinium chloride (GdCl3) as a potential contrast agent for NMR.
- To assess the acute toxicity of GdCl3 in a murine model.
- To measure the effects of GdCl3 on T1 relaxation times in various organs.
Main Methods:
- Acute toxicity was determined via intravenous injections of GdCl3 . 6 H2O in mice.
- T1 relaxation times were measured in plasma, kidney, liver, and brain of mice and rats.
- GdCl3 solutions at 60 mg gadolinium/kg were administered intravenously.
- Measurements were conducted using a Wh 270 Brucker NMR apparatus at 63 kG.
Main Results:
- The mean lethal dose (LD50) of GdCl3 . 6 H2O was determined to be 100-200 mg/kg.
- Intravenous injection of GdCl3 significantly decreased T1 relaxation times.
- Observed decreases in T1 were most pronounced in plasma, kidney, and liver tissues.
Conclusions:
- Gadolinium chloride (GdCl3) demonstrates potential as an effective NMR contrast agent.
- The agent significantly alters proton T1 relaxation in key organs.
- Acute toxicity studies provide initial safety data for GdCl3 administration.