Related Experiment Videos
[UFT concentration in various tissues from cancer patients]
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 1, 1983
Summary
UFT, an antitumor drug, showed higher concentrations of 5-fluorouracil (5-FU) in cancer tissues compared to non-cancerous sites. This suggests UFT is a potentially effective chemotherapy agent for various cancers.
Area of Science:
- Oncology
- Pharmacology
- Cancer Research
Context:
- Preoperative administration of UFT (Tegafur and Uracil) in 23 cancer patients.
- Inclusion of diverse cancer types: breast, gastric, colon, and others.
- Collection of tissue specimens from various sites, including cancerous and normal tissues, lymph nodes, and fatty tissues.
Purpose:
- To quantify the concentrations of tegafur (FT), 5-fluorouracil (5-FU), and uracil in different tissues after UFT administration.
- To compare drug concentrations in cancerous versus non-cancerous tissues.
- To evaluate the efficacy of UFT in cancer chemotherapy.
Summary:
- UFT administration resulted in higher 5-FU and uracil concentrations in cancer tissues compared to non-cancerous tissues.
- Tegafur and 5-FU fractions were elevated in cancer tissues from UFT-treated patients versus those receiving only Tegafur.
- Very low 5-FU levels were observed in patients with benign tumors, indicating drug specificity.
Impact:
- Suggests UFT is a useful drug for cancer chemotherapy.
- Provides data on drug distribution and concentration in various tumor microenvironments.
- Highlights potential for targeted drug delivery and efficacy assessment in oncology.