Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gonadal function in men treated for acute leukaemia.

J Waxman, Y Terry, L H Rees

    British Medical Journal (Clinical Research Ed.)
    |October 15, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Disruption of androgen receptor-cofactor interactions by the RNA-binding protein FUS/TLS alters androgen signalling in prostate cancer.

    Oncogene·2026
    Same author

    Circulating microRNAs as potential new biomarkers for prostate cancer.

    British journal of cancer·2013
    Same author

    Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer.

    British journal of cancer·2012
    Same author

    Current management of prostate cancer: dilemmas and trials.

    The British journal of radiology·2012
    Same author

    Advances in the treatment of pancreatic neuroendocrine tumours.

    QJM : monthly journal of the Association of Physicians·2012
    Same author

    Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.

    British journal of cancer·2012

    Men treated for leukaemia may experience lasting gonadal dysfunction. Acute myeloid leukaemia patients often recover testicular function, unlike those with acute lymphatic leukaemia, indicating gonadal failure post-treatment.

    Area of Science:

    • Oncology
    • Endocrinology
    • Reproductive Medicine

    Background:

    • Leukaemia treatment, including chemotherapy and cranial irradiation, can impact reproductive health.
    • Assessing long-term gonadal function in leukaemia survivors is crucial for patient management and counselling.

    Purpose of the Study:

    • To evaluate the gonadal function in men who have achieved remission from leukaemia.
    • To differentiate between gonadal and pituitary causes of infertility in these patients.

    Main Methods:

    • Hormonal assays were performed to assess endocrine function.
    • Sperm analysis (counts and motility) was conducted to evaluate testicular function.
    • Eight male patients in leukaemia remission were studied, with follow-up ranging from 8 months to 8 years post-treatment.

    Related Experiment Videos

    Main Results:

    • Four patients treated for acute myeloid leukaemia showed normal sperm counts and motility.
    • Only one of four patients with acute lymphatic or undifferentiated leukaemia had normal sperm parameters.
    • Hormonal data suggested gonadal failure, not pituitary dysfunction, as the cause of sterility, even after cranial irradiation.

    Conclusions:

    • Leukaemia survivors, particularly those with acute lymphatic or undifferentiated leukaemia, may face significant gonadal failure.
    • The findings highlight the importance of reproductive health assessment and counselling for leukaemia patients.
    • Distinguishing between gonadal and pituitary dysfunction is key for understanding and managing infertility in this population.