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Related Experiment Videos

Morphological changes at the basement membrane during some tissue interactions in the integument.

M H Hardy, E A Goldberg

    Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire
    |August 1, 1983
    PubMed
    Summary

    During vibrissa follicle development, gaps in the basement membrane

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    Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 1. Follicle morphogenesis in wild-type mice.

    Acta anatomica·1996

    Area of Science:

    • Developmental biology
    • Cell biology
    • Histology

    Background:

    • Basement membrane changes are crucial during integumentary organ development.
    • Previous in vitro studies showed gaps in the lamina densa during vibrissa follicle differentiation.

    Purpose of the Study:

    • To investigate basement membrane changes in vivo during mouse vibrissa follicle development.
    • To explore the role of the lamina densa in epithelial-mesenchymal interactions.

    Main Methods:

    • In vivo study of mouse vibrissa follicle development.
    • Enzyme treatment and chelating agents to separate epithelial and dermal papilla cells.
    • Scanning and transmission electron microscopy to examine cell surfaces.

    Main Results:

    • Gaps in the lamina densa were observed in vivo during specific stages of vibrissa follicle development.
    • Mesenchymal cell processes from the dermal papilla traversed these gaps.
    • Direct cell-to-cell contacts occurred before epithelial differentiation into inner root sheath and hair.

    Conclusions:

    • The study suggests that transient gaps in the basement membrane facilitate instructive cell-surface interactions.
    • These interactions are critical for guiding epithelial cell differentiation during hair follicle morphogenesis.

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