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Effect of hypertonic mannitol infusion during prolonged coronary occlusion
Cardiovascular Research
|September 1, 1983
Summary
Hypertonic mannitol infusion did not improve myocardial blood flow or reduce tissue damage during prolonged coronary artery occlusion in dogs. Mannitol failed to prevent cell swelling, suggesting a potential reason for its ineffectiveness in this model.
Area of Science:
- Cardiovascular Physiology
- Ischemic Heart Disease Research
Background:
- Conflicting results exist regarding hypertonic mannitol's efficacy during coronary occlusion.
- Myocardial ischemia leads to reduced blood flow, increased metabolic markers, and cellular swelling.
Purpose of the Study:
- To investigate the effect of hypertonic mannitol on myocardial blood flow, ischemia severity, and water accumulation during prolonged coronary artery occlusion.
Main Methods:
- Utilized the microsphere technique to measure regional myocardial blood flow in anesthetized dogs.
- Assessed myocardial PCO2 (PmCO2) as an index of ischemic severity.
- Quantified myocardial water content to evaluate cellular swelling after 2-hour left anterior descending (LAD) artery occlusion.
Main Results:
- LAD ligation significantly reduced regional blood flow and increased PmCO2 and myocardial water content in the absence of mannitol.
- Mannitol infusion increased plasma osmolarity but did not alter regional blood flow, PmCO2, or water accumulation in ischemic tissue.
Conclusions:
- Hypertonic mannitol infusion was ineffective in mitigating myocardial ischemia severity or cellular swelling during prolonged LAD occlusion in this canine model.
- Mannitol's failure may stem from its inability to prevent myocardial cell swelling, warranting further investigation into its therapeutic potential.