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A unique DR-related B cell differentiation antigen.

M A Shipp, B D Schwartz, C C Kannapell

    Journal of Immunology (Baltimore, Md. : 1950)
    |November 1, 1983
    PubMed
    Summary

    Researchers identified a novel human Ia antigen, K19, distinct from DR antigens. This K19 molecule is specifically found on mature B lymphocytes, suggesting a new Ia-like molecule with selective expression.

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    Area of Science:

    • Immunology
    • Human genetics
    • Cell biology

    Background:

    • The immune response in humans and mice is genetically controlled by Class II (Ia) molecules.
    • Several human Class II antigens, including DR, have been identified.

    Purpose of the Study:

    • To describe a newly discovered human Ia antigen, designated K19.
    • To characterize the biochemical properties and cellular expression of this novel antigen.

    Main Methods:

    • Utilized three monoclonal antibodies (HK-9, HK-19, HK-20) for antigen recognition.
    • Performed biochemical characterization of the antigen.
    • Analyzed antigen expression on various human immune cells.

    Main Results:

    • Identified a new human Ia antigen, K19, recognized by specific monoclonal antibodies.

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  • K19 shares general biochemical traits with Ia antigens but differs from DR antigens.
  • K19 is exclusively expressed on mature B lymphocytes, not on monocytes or activated T cells.

    • Conclusions:

    • K19 represents a novel Ia-like molecule in humans.
    • This molecule exhibits preferential expression on mature B cells, distinguishing it from other known Ia antigens.