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[Production of delayed-release formulations based on hydrophilic matrix forms using polyvinyl alcohol]
Die Pharmazie
|July 1, 1983
Abstract:
By increasing the drug concentration or the porosity of the mouldings, the liberation rate of the drug is increased. Dependently on their wetting behaviour and concentration, insoluble solids may exert varied effects on the liberation rate. The rate of swelling and, thus, the disintegration time and the release can be controlled by the addition of magnesium stearate or potato starch.