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Related Experiment Videos

[18F]fluorodeoxyglucose positron emission tomography in refractory complex partial seizures.

W H Theodore, M E Newmark, S Sato

    Annals of Neurology
    |October 1, 1983
    PubMed
    Summary

    Positron emission tomography ([18F]fluorodeoxyglucose) identified hypometabolic lesions in 16 of 20 epilepsy patients. This imaging technique effectively localized seizure foci, even when electroencephalography showed non-specific abnormalities.

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    Letters.

    The Israel Medical Association journal : IMAJ·2017

    Area of Science:

    • Neurology
    • Nuclear Medicine

    Background:

    • Complex partial seizures (CPS) often require precise localization for effective treatment.
    • Standard computed tomography (CT) scans may not reveal the underlying pathology in some epilepsy cases.

    Purpose of the Study:

    • To evaluate the utility of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) in localizing seizure foci in patients with CPS and normal CT scans.
    • To assess the correlation between FDG-PET findings and electroencephalography (EEG) in these patients.

    Main Methods:

    • Twenty patients with CPS and normal CT scans underwent simultaneous electroencephalography (EEG) and [18F]fluorodeoxyglucose positron emission tomography (FDG-PET).
    • EEG data included localization of epileptiform discharges (unilateral, predominantly unilateral, or nonlocalized).

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  • FDG-PET assessed regional cerebral glucose metabolism.

    • Main Results:

    • FDG-PET revealed hypometabolic lesions in 16 out of 20 patients.
    • Pathological confirmation was obtained in 4 of 5 surgically treated patients.
    • FDG-PET findings were independent of seizure frequency, alertness, or spike discharge count during the scan.
    • Seizures during FDG uptake created hypermetabolic areas at the hypometabolic focus.
    • PET sometimes indicated more widespread hypometabolism than suggested by EEG.

    Conclusions:

    • FDG-PET is a valuable tool for identifying focal lesions in patients with CPS, particularly when EEG localization is uncertain or CT is normal.
    • This imaging modality can precisely delineate hypometabolic areas associated with epileptic foci.
    • FDG-PET findings can guide surgical planning and improve treatment outcomes for refractory epilepsy.