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Related Experiment Videos

Asthma in childhood.

E F Ellis

    The Journal of Allergy and Clinical Immunology
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Asthma is a chronic airway disease characterized by inflammation and hyperresponsiveness. While its exact prevalence is debated, childhood asthma often improves with age and management.

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    Area of Science:

    • Pulmonology
    • Pediatrics
    • Genetics

    Background:

    • Asthma is an obstructive pulmonary disease involving airway muscle spasm, mucus, and inflammation.
    • Airway hyperresponsiveness to various stimuli is a key feature, potentially linked to genetic factors.
    • Two main theories propose defects in beta-adrenergic receptor-adenylate cyclase function or increased cholinergic activity.

    Purpose of the Study:

    • To define asthma and discuss its prevalence, risk factors, and clinical spectrum in children.
    • To outline management goals and therapeutic strategies for pediatric asthma.
    • To assess the prognosis of childhood asthma.

    Main Methods:

    • Literature review and synthesis of existing studies on asthma definition, prevalence, and risk factors.

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  • Analysis of clinical presentation, progression, and management approaches in pediatric asthma.
  • Evaluation of treatment outcomes and long-term prognosis based on available data.

    • Main Results:

    • Asthma prevalence in children varies widely (1.37%–11.4%+), with a male predominance.
    • Risk factors include atopy, lower respiratory infections, parental smoking, and bronchiolitis.
    • Most children show improvement during childhood and adolescence, with good prognosis.

    Conclusions:

    • Asthma management aims to minimize symptoms for daily activities while avoiding adverse drug effects.
    • Non-pharmacologic and pharmacologic treatments (adrenergics, theophylline, cromolyn, corticosteroids) are key.
    • Despite potential lifelong airway abnormalities, most children achieve symptom-free status.