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Related Experiment Videos

Hypothalamic-pituitary-thyroid axis in acromegaly.

E Carmina, F Rosato, S Pirronello

    Journal of Endocrinological Investigation
    |August 1, 1983
    PubMed
    Summary
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    Acromegaly often alters thyroid-stimulating hormone (TSH) response to TRH, despite normal thyroid function. Treatment of acromegaly can normalize TSH secretion, suggesting hypothalamic influence.

    Area of Science:

    • Endocrinology
    • Neuroendocrinology

    Background:

    • Acromegaly, characterized by excessive growth hormone (GH) production, can impact various endocrine axes.
    • The hypothalamic-pituitary-thyroid axis is a critical regulatory system that may be affected by GH hypersecretion.

    Purpose of the Study:

    • To investigate the hypothalamic-pituitary-thyroid axis function in patients with acromegaly.
    • To assess thyroid hormone levels and the TSH response to TRH in acromegalic individuals.

    Main Methods:

    • Evaluated total and free thyroid hormones and TSH response to TRH in 36 acromegalic patients.
    • Assayed reverse T3 (rT3) and thyroxine-binding globulin (TBG) in 10 patients.
    • Studied TSH response to TRH before and after therapy in 15 patients.

    Main Results:

    Related Experiment Videos

    • Most patients (34/36) had normal total thyroid hormones; two had low free thyroid hormones.
    • 32 patients were euthyroid, but only 43.7% exhibited a normal TSH response to TRH.
    • Abnormal TSH responses (reduced, exaggerated, delayed) were observed; rT3 and TBG levels were normal.
    • Therapy for acromegaly improved or normalized TSH response to TRH.

    Conclusions:

    • The TSH response to TRH is frequently altered in acromegaly, while overall thyroid function remains largely normal.
    • Hypothalamic effects secondary to GH hyperproduction likely contribute to altered TSH secretion.
    • Normalization of TSH secretion post-acromegaly treatment supports the role of GH excess in these pituitary-thyroid axis dysregulations.