Effect of soybean protein on coprostanol production and cholesterol metabolism in cholesterol-fed rats

The effect of soybean protein on coprostanol production and cholesterol metabolism was studied in cholesterol-fed rats. Plasma cholesterol was decreased in the soybean protein diet group compared to the casein diet group. Although coprostanol was produced more in rats fed soybean protein than in those fed casein, no difference was observed in the levels of total neutral steroids at any part of the intestine. The activity of microbial conversion from cholesterol to coprostanol was evidently high in rats fed soybean protein. The total amount of neutral steroids excreted in feces had a tendency to increase. These data seem to indicate that the increase of the unabsorbed soybean protein causes the increase of intestinal coprostanol production.