Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationship between osmolality and osmolarity.

W H Streng, H E Huber, J T Carstensen

    Journal of Pharmaceutical Sciences
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Osmotic properties of sulfobutylether and hydroxypropyl cyclodextrins.

    Pharmaceutical research·2001
    Same author

    Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.

    Journal of the American Chemical Society·2001
    Same author

    Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.

    Bioorganic & medicinal chemistry letters·2001
    Same author

    2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.

    Bioorganic & medicinal chemistry letters·2001
    Same author

    Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors.

    The Journal of biological chemistry·2001
    Same author

    Inert gas sparge leads to alternate reaction pathway.

    The Journal of pharmacy and pharmacology·2000
    Same journal

    Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

    Journal of pharmaceutical sciences·2026
    Same journal

    Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

    Journal of pharmaceutical sciences·2026
    Same journal

    Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

    Journal of pharmaceutical sciences·2026
    Same journal

    Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

    Journal of pharmaceutical sciences·2026
    Same journal

    A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

    Journal of pharmaceutical sciences·2026
    Same journal

    Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

    Journal of pharmaceutical sciences·2026
    See all related articles

    Converting osmolality to osmolarity is crucial for parenteral labeling. This study establishes a physical-chemical relationship, showing osmolarity depends on osmotic coefficient and partial molal volume, with a concentration-independent conversion factor.

    Area of Science:

    • Physical Chemistry
    • Pharmaceutical Sciences
    • Solution Thermodynamics

    Background:

    • Parenteral formulations require accurate osmolarity labeling as per compendia standards.
    • Experimental measurement typically yields osmolality, not osmolarity.
    • A reliable method to convert measured osmolality to required osmolarity is needed.

    Purpose of the Study:

    • To establish the fundamental physical-chemical relationship between osmolality and osmolarity.
    • To determine the necessary parameters for accurate conversion.
    • To provide a basis for consistent labeling of parenteral solutions.

    Main Methods:

    • Utilized fundamental physical-chemical definitions to derive the relationship.
    • Analyzed the role of the osmotic coefficient in osmolality determination.

    Related Experiment Videos

  • Incorporated partial molal volumes of solutes for osmolarity conversion.

    • Main Results:

    • Osmolality is directly related to the osmotic coefficient of a solution.
    • Conversion of osmolality to osmolarity requires partial molal volume data.
    • A single, concentration-independent conversion factor exists for specific solute systems.

    Conclusions:

    • A clear physical-chemical pathway exists to convert osmolality to osmolarity.
    • Partial molal volume is a key determinant in this conversion.
    • The derived method allows for accurate and consistent labeling of parenteral products.