B-cell malignancies and differentiation antigens defined with monoclonal antibodies

Monoclonal antibodies directed to B-cell lineage were produced. They were characterized by their reactivity with a variety of human hematopoietic cell lines and normal lymphoid cells and by the immunohistological distribution of cells positive for the antibodies. Some of them were specific for B-cell lineage at various stages of B-cell differentiation and some were, in addition, cross-reactive with other cell lineages. These newly produced antibodies were utilized to dissect and characterize B-cell malignancies and were applied for classification of B-cell malignancies.