Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Griseofulvin---phenobarbital interaction: a formulation-dependent phenomenon.

F Jamali, J E Axelson

    Journal of Pharmaceutical Sciences
    |April 1, 1978
    PubMed
    Summary

    Phenobarbital reduces griseofulvin absorption, but this drug interaction depends on the formulation. Changing the polysorbate 80 concentration altered the interaction

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Erratum to Clinical Pharmacokinetics of Ketorolac Tromethamine.

    Clinical pharmacokinetics·2016
    Same author

    From the bench to clinical practice: understanding the challenges and uncertainties in immunogenicity testing for biopharmaceuticals.

    Clinical and experimental immunology·2015
    Same author

    [Not Available].

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015
    Same author

    [Not Available].

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015
    Same author

    Endoscopic removal of a bleeding colonic polypoid angiodysplasia: case report.

    Acta gastro-enterologica Belgica·2010
    Same author

    Central hepatectomy for hepatic mesenchymal hamartoma in children.

    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie·2009

    Area of Science:

    • Pharmacology
    • Drug Interactions
    • Drug Absorption

    Background:

    • Griseofulvin is an antifungal medication.
    • Phenobarbital is an anticonvulsant drug.
    • Potential interactions between griseofulvin and phenobarbital have been reported.

    Purpose of the Study:

    • To investigate the interaction between griseofulvin and phenobarbital in rats.
    • To determine the influence of different dosage forms on this interaction.
    • To elucidate the mechanisms underlying the observed drug interaction.

    Main Methods:

    • Oral administration of griseofulvin and phenobarbital to rats.
    • Utilizing various formulations for griseofulvin administration, including suspensions and solutions with different excipients (polysorbate 80, polyethylene glycol 300, polyethylene glycol 600).
    • Quantification of plasma griseofulvin levels to assess absorption and interaction effects.

    Main Results:

    • A phenobarbital pretreatment significantly reduced plasma griseofulvin levels when griseofulvin was administered in a 0.5% polysorbate 80 suspension.
    • Increasing polysorbate 80 concentration to 2% diminished the extent of this interaction.
    • Phenobarbital did not affect griseofulvin plasma levels when griseofulvin was formulated with polyethylene glycol 300 or 100% polyethylene glycol 600.

    Conclusions:

    • The interaction between phenobarbital and griseofulvin is formulation-dependent.
    • Diminished dissolution and subsequent reduced absorption of griseofulvin contribute to the observed interaction.
    • Careful consideration of drug formulation is crucial when co-administering these medications.

    Related Experiment Videos