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Indican excretion in the elderly.

J L Kirkland, E Vargas, M Lye

    Postgraduate Medical Journal
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Urinary indican levels are similar in young and elderly individuals, challenging the notion that older adults have higher concentrations. Diurnal variations may impact qualitative test accuracy in all age groups.

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    Area of Science:

    • Gerontology
    • Clinical Chemistry
    • Biochemistry

    Background:

    • Previous suggestions indicated higher urinary indican concentrations in elderly hospitalized patients compared to younger individuals.
    • This observation raised concerns about the validity of qualitative urinary indican tests in the aged population.
    • Indican, a metabolic byproduct, is often monitored as an indicator of certain physiological processes.

    Purpose of the Study:

    • To investigate urinary indican concentrations in young, healthy elderly, and disabled elderly individuals.
    • To evaluate the accuracy of the standard colorimetric qualitative test for urinary indican excess in different age groups.
    • To determine if age significantly influences urinary indican levels.

    Main Methods:

    • Involved 21 young control subjects, 18 healthy elderly subjects, and 23 disabled elderly long-stay patients.

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  • Utilized a standard colorimetric qualitative test for initial screening.
  • Employed a quantitative assay to precisely measure urinary indican concentration.

    • Main Results:

    • No participants, regardless of age or health status, showed detectable indican levels using the qualitative test.
    • Quantitative assays revealed similar urinary indican concentrations in both young and elderly individuals.
    • A significant diurnal variation in urinary indican concentration was identified.

    Conclusions:

    • The commonly used qualitative test for urinary indican excess appears unreliable across all tested age groups.
    • Urinary indican concentration does not significantly differ between young and elderly individuals.
    • Diurnal variations in urinary indican levels necessitate careful consideration during test interpretation.